Physiologists have always been challenged by the adjustments of the human body to hostile
environments. The set of papers in this issue of The Journal of Physiology (Cox et al. 2002; …

Orthostatic intolerance is common when astronauts return to Earth: after brief spaceflight, up
to two‐thirds are unable to remain standing for 10 min. Previous research suggests that …

Astronauts returning from space have reduced red blood cell masses, hypovolaemia and
orthostatic intolerance, marked by greater cardio–acceleration during standing than before …

Orthostatic intolerance (OI) is common after space flight and resembles the disabling
idiopathic orthostatic intolerance commonly observed in otherwise healthy young …

Astronauts returning to Earth have reduced orthostatic tolerance and exercise capacity.
Alterations in autonomic nervous system and neuromuscular function after spaceflight might …

Purpose: Orthostatic stability on Earth is maintained through sympathetic nerve activation
sufficient to increase peripheral vascular resistance and defend against reductions of blood …

Impaired cardiovascular function, characterized by orthostatic intolerance and reduced
exercise capacity, is a result of space travel. We hypothesized that postflight baroreflex …

The development of orthostatic hypotension and instability immediately after return from
spaceflight has been a significant operational problem to astronauts for more than four …

Abstract Aim: Astronauts return to Earth with reduced red cell masses and hypovolaemia.
Not surprisingly, when they stand, their heart rates may speed inordinately, their blood …

Cardiac output is increased by some 18% by weightlessness during the initial week of
spaceflight compared to upright standing or sitting on the ground and more so during the …