It is now generally recognized that atherosclerosis is a chronic inflammatory disease,
characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Atherosclerosis is a chronic inflammatory process and both the innate and adaptive immune
systems 1 play central roles in its initiation and subsequent progression. 2 Experimental …

Atherosclerosis represents the most common pathological substrate of coronary heart
disease (CHD), and the characterization of the disease as a chronic low-grade inflammatory …

Despite considerable advances in reducing the global burden of atherosclerotic
cardiovascular disease by targeting conventional risk factors, significant residual risk …

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Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

Contrary to popular opinion, atherosclerosis is not a disease unique to modern civilization.
In fact, atherosclerotic lesions have been found in the arteries of mummies dating back to …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque
formation to rupture and ultimately to thrombosis. Insight gained from recent basic and …