Many neurodegenerative diseases are associated with distinctive brain lesions. One
particular group of heterogeneous dementias and movement disorders is characterized by …

Tau is a microtubule-associated protein that normally interacts in monomeric form with the
neuronal cytoskeleton. In Alzheimer's disease, however, it aggregates to form the structural …

Neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease
involves abnormal aggregation and accumulation of toxic proteins aggregates. Post …

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …

Featured Article: Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple
isoforms of human microtubule-associated protein tau: sequences and localization in …

Tauopathies including Alzheimer's disease (AD) are neurodegenerative disorders
accompanied by the conversion of functional forms of the microtubule associated protein …

Tau hyperphosphorylation is a central event in the development of Alzheimer's Disease
(AD). Protein phosphatase 2A (PP2A) heterotrimer formation is necessary for efficient …

Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be classified as
tauopathies, which are a group of neurodegenerative diseases that develop toxic tau …

In Alzheimer's disease, the microtubule-associated protein tau dissociates from the neuronal
cytoskeleton and aggregates to form cytoplasmic inclusions. Although hyperphosphorylation …

The changes of insulin signaling, calcium signaling, mitochondrial decline and oxidative
stress have been implicated in the hyperphosphorylation of tau protein found in Downs …