Capsaicin desensitization of peripheral nociceptive fibres does not impair sensitivity to other noxious stimuli
A Dray, J Bettaney, P Forster - Neuroscience letters, 1989 - Elsevier
Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …
depolarization or desensitization were likely to explain the antinociception observed after …
Antinociception produced by capsaicin: spinal or peripheral mechanism?
A Dickenson, N Ashwood, AF Sullivan, I James… - European journal of …, 1990 - Elsevier
We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …
Actions of capsaicin on peripheral nociceptors of the neonatal rat spinal cord‐tail in vitro: dependence of extracellular ions and independence of second messengers
A Dray, J Bettaney, P Forster - British journal of pharmacology, 1990 - Wiley Online Library
1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
Capsaicin desensitization to plasma extravasation evoked by antidromic C-fiber stimulation is not associated with antinociception in the rat
RB Carter, WR Francis - Neuroscience letters, 1991 - Elsevier
The relationship of capsaicin desensitization to the antinociception produced by acute
capsaicin administration was studied in the rat. Cutaneous application of 1% capsaicin …
capsaicin administration was studied in the rat. Cutaneous application of 1% capsaicin …
Neuropharmacological mechanisms of capsaicin and related substances.
A Dray - Biochemical pharmacology, 1992 - europepmc.org
Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …
Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans
M Grönroos, A Pertovaara - Neuroscience letters, 1993 - Elsevier
The effect of selective activation of nociceptive primary afferent fibers by capsaicin on a
nociceptive lower limb flexion reflex was studied in healthy human subjects. Capsaicin (1%) …
nociceptive lower limb flexion reflex was studied in healthy human subjects. Capsaicin (1%) …
NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro
A Dray, J Bettaney, A Rueff, C Walpole… - European journal of …, 1990 - Elsevier
When applied to peripheral fibres in a neonatal rat tail/spinal cord preparation in vitro,
capsaicin (0.2–50 μM) induced an activation, selective desensitization and reduced …
capsaicin (0.2–50 μM) induced an activation, selective desensitization and reduced …
Capsaicin: actions on nociceptive C-fibres and therapeutic potential
B Lynn - Pain, 1990 - Elsevier
Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
MN Perkins, EA Campbell - British journal of pharmacology, 1992 - ncbi.nlm.nih.gov
This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …
persistent nocifensor behavioural models and to determine whether this was mediated via a …
The depolarising action of capsaicin on rat isolated sciatic nerve
AG Hayes, AB Hawcock, RG Hill - Life sciences, 1984 - Elsevier
The effect of capsaicin on the isolated sciatic nerve of rat was studied by extracellular
recording of membrane polarisation. Capsaicin depolarised the sciatic nerve, but …
recording of membrane polarisation. Capsaicin depolarised the sciatic nerve, but …