Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

The heterogeneity of cellular states in cancer has been linked to drug resistance, cancer
progression and the presence of cancer cells with properties of normal tissue stem cells …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer
prognosis than young. This may be due to accumulated cellular damage, decreases in …

Many organs with a high cell turnover (for example, skin, intestine and blood) are composed
of short-lived cells that require continuous replenishment by somatic stem cells,. Ageing …

Metastatic growth in distant organs is the major cause of cancer mortality. The development
of metastasis is a multistage process with several rate-limiting steps. Although dissemination …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

Early detection and treatment are critical for improving the outcome of patients with cancer.
Understanding the largely uncharted biology of carcinogenesis requires deciphering …