The retinoblastoma gene (RB-1) was originally identified as the gene involved in hereditary
retinoblastoma. However, RB-1 mutations are found in a number of common mesenchymal …

Genetic evidence from retinoblastoma patients and experiments describing the mechanism
of cellular transformation by the DNA tumor viruses have defined a central role for the …

The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene
products. Its loss during the genesis of many human tumours, its inactivation by several DNA …

Retinoblastoma has contributed much to the understanding of cancer. The protein product of
the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

Tumor formation results from alterations in the control of normal cell proliferation. To further
our understanding of the molecular mechanisms underlying the deregulation of cell …

Although the precise function of the retinoblastoma gene product, pl lO P~ 1, remains
unknown, recent data suggest that it plays a role in the control of ceUular proliferation by …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …