Solid tumors remain a major challenge for targeted therapeutic intervention strategies such
as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid …

Many tumors express proteoglycans modified with oncofetal chondroitin sulfate
glycosaminoglycan chains (ofCS), which are normally restricted to the placenta. However …

Considering the high mortality of ovarian cancer, novel approaches for diagnostics and
therapy are urgently needed. Cancer initiation, progression, and invasion occur in a …

Molecular similarities between embryonic and malignant cells can be exploited to target
tumors through specific signatures absent in healthy adult tissues. One such embryonic …

Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS
modifications might be potential targets to influence tumor development. We applied the …

The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

Breast cancer is one of the leading causes of cancer-related deaths amongst women in the
USA. The tumor microenvironment has been suggested to be an attractive therapeutic target …

Objective The extracellular matrix (ECM) of ovarian cancer may provide a number of
potential biomarkers. Chondroitin sulfate (CS), a class of sulfated polysaccharides, is …

Experimental studies have established that the sulfated glycosaminoglycans heparan
sulfate and chondroitin sulfate act as co-receptors of cytokines and growth factors that drive …

High mortality in ovarian cancer patients is primarily caused through rapid metastasis of the
tumour, but the underlying mechanisms are poorly understood. Glycosaminoglycans, are …