Smilax china L. Polysaccharide Alleviates Oxidative Stress and Protects From Acetaminophen-Induced Hepatotoxicity via Activating the Nrf2-ARE Pathway

K Wang, L Yang, J Zhou, X Pan, Z He, J Liu… - Frontiers in …, 2022 - frontiersin.org
The alleviation of oxidative stress is considered an effective treatment for acetaminophen
(APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential …

Hepatoprotective effect of neoagarooligosaccharide via activation of Nrf2 and enhanced antioxidant efficacy

JH Yang, CS Na, SS Cho, KM Kim, JH Lee… - Biological and …, 2020 - jstage.jst.go.jp
Neoagarooligosaccharides (NAOS) are generated by β-agarases, which cleave the β-1, 4
linkage in agarose. Previously, we reported that NAOS inhibited fat accumulation in the liver …

Seabuckthorn berry polysaccharide extracts protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2/HO-1-SOD-2 signaling pathway

X Wang, J Liu, X Zhang, S Zhao, K Zou, J Xie, X Wang… - Phytomedicine, 2018 - Elsevier
Background Oxidative stress is concomitant with acetaminophen (APAP)-induced
hepatotoxicity, which has been highlighted as therapeutic targets for such diseases. The …

Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen‐Induced Liver Injury in Mice via Regulation of the Nrf2 …

G Lin, D Luo, J Liu, X Wu, J Chen… - Oxidative Medicine …, 2018 - Wiley Online Library
The effect of polysaccharides isolated from Dendrobium officinale (DOP) on acetaminophen‐
(APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated …

Salvianolic acid C against acetaminophen‐induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the Keap1/Nrf2 …

CT Wu, JS Deng, WC Huang, PC Shieh… - Oxidative medicine …, 2019 - Wiley Online Library
Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in …

P Cao, J Sun, MA Sullivan, X Huang, H Wang… - International journal of …, 2018 - Elsevier
Acetaminophen (APAP)-induced hepatic damage is prevalent in western countries. The
present study aimed to investigate the hepatoprotective effects of Angelica sinensis …

Protective effect and mechanism of chitooligosaccharides on acetaminophen-induced liver injury

J Xiang, J Wang, H Xie, Y Liu, Y Bai, Q Che, H Cao… - Food & Function, 2021 - pubs.rsc.org
Currently, drug-induced liver injury caused by acetaminophen (APAP) is the second leading
cause of human liver transplantation. The only clinical antidote treatment for APAP-induced …

Aged citrus peel (chenpi) prevents acetaminophen-induced hepatotoxicity by epigenetically regulating Nrf2 pathway

ZH Lin, YF Chan, MH Pan, YC Tung… - The American Journal of …, 2019 - World Scientific
Excessive consumption of analgesic drug acetaminophen (APAP) can cause severe
oxidative stress-mediated liver injury. Here, we investigated the protective effect and …

[HTML][HTML] Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation

W Tian, J Zhao, MK Kim, HJ Tae, IS Kim, D Ahn… - Biomedicine & …, 2023 - Elsevier
Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …

Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Nrf2/NF-κB/caspase signaling pathway

J Zhao, S Shi, X Zhang, Y Liu, M Yuan, G Cheng… - Food & Function, 2023 - pubs.rsc.org
Dihydrochalcones are important bioactive ingredients in plants. Anneslea fragrans is an
edible and medicinal plant, and its leaves are rich in dihydrochalcones. Confusoside (CF) is …