Abstract Anti-programmed death-1 (PD-1) therapy has been extensively used to treat
cancer. Recently, the combination of immunotherapy and anti-angiogenic therapy has …

Abstract Background The PD-L1 antibody is an immune checkpoint inhibitor (ICI) attracting
attention. The third-generation anticancer drug has been proven to be very effective due to …

Background—Cell-mediated immunity is considered to contribute to the pathogenesis of
abdominal aortic aneurysms (AAA). In particular, infiltrating macrophages and CD8+ T …

Background and Aims. The nacht domain, leucine‐rich repeat, and pyrin domain‐containing
protein 3 (NLRP3) inflammasome is upregulated in human abdominal aortic aneurysm …

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

Immunotherapy has become one of the most attraction cancer therapy strategies. The PD-
1/PD-L1 pathway plays key roles in immune responses and autoimmunity by regulating T …

Programmed death ligand-1 (PD-L1) plays a critical role in T-cell regulatory function. Here,
we report a newly discovered effect of PD-L1 on angiogenesis. We demonstrate that PD-L1 …

Objective—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis
remains unknown and no specific medical therapies are available. We sought to evaluate …

BACKGROUND: Co-stimulatory molecules are pivotal for T cell activation. It is increasingly
recognized that programmed death ligand 1 (PD-L1) is a novel co-stimulatory molecule …

Aortic aneurysms, particularly abdominal aortic aneurysms (AAAs), exhibit sex differences,
with higher prevalence and severity in males than females, both in humans and …