In both multiple sclerosis and its model experimental autoimmune encephalomyelitis (EAE),
the extent of resident microglia activation and infiltration of monocyte-derived cells to the …

In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Macrophages can be of dual origin. Most tissue-resident macrophage compartments are
generated before birth and subsequently maintain themselves independently from each …

Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Specialized populations of tissue-resident myeloid cells inhabit every organ of the body.
While many of these populations appear similar morphologically and phenotypically, they …

Objective Myeloid cells, including macrophages and dendritic cells, are a prominent
component of central nervous system (CNS) infiltrates during multiple sclerosis (MS) and the …

In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

Macrophages predominate the inflammatory landscape within multiple sclerosis (MS)
lesions, not only regarding cellularity but also with respect to the diverse functions this cell …