The initial cohort of mammalian gametes is established by the proliferation of primordial
germ cells in the early embryo. Primordial germ cells first appear in extraembyronic tissues …

Primordial germ cells (PGCs) sequentially induce specific genes required for their
development. We focused on epigenetic changes that regulate PGC-specific gene …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Primordial germ cells (PGCs) are embryonic progenitors for the gametes. In the gastrulating
mouse embryo, a small group of cells begin expressing a unique set of genes and so …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Remodeling DNA methylation in mammalian genomes can be global, as seen in
preimplantation embryos and primordial germ cells (PGCs), or locus specific, which can …

The discovery of DNA methylation has provided a new perspective on how DNA may be
dynamically regulated in the mammalian genome. DNA methylation is a dynamic process …

In mice, unique events regulating epigenetic programming (eg, genomic imprinting) and
replication state (mitosis versus meiosis) occur during fetal germ cell development. To …

DNA methylation is necessary for the silencing of endogenous retrotransposons and the
maintenance of monoallelic gene expression at imprinted loci and on the X chromosome …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …