Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder
caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency …

Abstract β-Sarcoglycan, one of the subunits of the sarcoglycan complex, is a
transmembranous glycoprotein which associates with dystrophin and is the molecule …

Limb-girdle muscular dystrophy type 2E (LGMD 2E) is caused by mutations in the β-
sarcoglycan gene, which is expressed in skeletal, cardiac, and smooth muscle. β …

Four types of limb-girdle muscular dystrophy (LGMD) are known to be caused by mutations
in distinct sarcoglycan genes. The BIO 14.6 hamster is a model for sarcoglycan-deficient …

The sarcoglycans are transmembrane components of the dystrophin-glycoprotein complex,
which links the cytoskeleton to the extracellular matrix in adult muscle fibers. Mutations in all …

The heterotetrameric sarcoglycan complex, composed of α-, β-, γ-, and δ-sarcoglycans, is an
important component of the dystrophin-associated glycoprotein assembly in striated muscle …

The dystrophin glycoprotein complex (DGC) is found at the plasma membrane of muscle
cells, where it provides a link between the cytoskeleton and the extracellular matrix. A …

The sarcoglycan complex is known to be involved in limb-girdle muscular dystrophy (LGMD)
and is composed of at least three proteins: α-, β-, and γ-sarcoglycan. δ-Sarcoglycan has now …

In humans, mutations in the genes encoding components of the dystrophin–glycoprotein
complex cause muscular dystrophy. Specifically, primary mutations in the genes encoding α …

The sarcoglycan complex has been well characterized in striated muscle, and defects in its
components are associated with muscular dystrophy and cardiomyopathy. Here, we have …