Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of
abdominal aortic aneurysms (AAAs). The purpose of this study was to define the contribution …

Increased plasma concentrations of angiotension II (Ang II) have been implicated in
atherogenesis. To examine this relationship directly, we infused Ang II or vehicle for 1 month …

Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost
10% of the population over age 65. Generation of AAAs by infusion of angiotensin (Ang) II in …

The purpose of this study was to determine the effect of chronic angiotensin II (AngII)
infusion on the severity of the atherogenic process in low density lipoprotein (LDL) …

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …

Abdominal aortic aneurysms (AAA) have a high prevalence in aged populations and are
responsible for a large number of deaths. Despite the widespread nature of the disease …

Rationale: Human studies and mouse models have provided evidence for angiotensin II
(Ang II)–based mechanisms as an underlying cause of aneurysms localized to the …

Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) are two distinct
human vascular diseases that are not only distinguished by different locations but also by …

Osmotic pumps continuously deliver compounds at a constant rate into small animals. This
article introduces a standard protocol used to induce aortic aneurysms via subcutaneous …

AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into
human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal …