Inflammasomes are multimeric protein complexes that induce the cleavage and release of
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

Proteinuria serves as a direct causative factor of renal tubular cell injury and is highly
associated with the progression of chronic kidney disease via uncertain mechanisms …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney
fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator …

Damage-associated molecular patterns (DAMPs) such as extracellular ATP and nigericin (a
bacterial toxin) not only act as potassium ion (K+) efflux inducers to activate NLRP3 …

Endoplasmic reticulum (ER) stress and mitochondrial dysfunction, which are key events in
the initiation and/or progression of several diseases, are correlated with alterations at ER …

Abstract NOD-like receptor (NLR) X1 (NLRX1) is an ubiquitously expressed inflammasome-
independent NLR that is uniquely localized in mitochondria with as yet unknown effects on …

Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues,
followed by the restoration of perfusion and consequent reoxygenation. The reestablishment …

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern
recognition receptor that is implicated in the pathogenesis of inflammation and chronic …