There is significant progress in understanding the structure and function of NLRC5, a
member of the nucleotide oligomerization domain-like receptor family. However, in the …

Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor,
initiates lung inflammation through the NLR family pyrin domain containing 3 (NLRP3) …

Kidney in diabetic state is more sensitive to ischemic acute kidney injury (AKI). However, the
underlying mechanisms remain unclear. Herein, we examined the impact of diabetes …

NLRX1 is the only member of the Nod-like receptor (NLR) family that is targeted to the
mitochondria, and its overexpression induces the generation of reactive oxygen species …

Rationale LonP1 is an essential mitochondrial protease, which is crucial for maintaining
mitochondrial proteostasis and mitigating cell stress. However, the importance of LonP1 …

Lung injury, which is associated with systemic inflammatory responses, is a common
problem with significant morbidity and mortality. Here, we examined the involvement of toll …

Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form
inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D …

Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

The NLRP3-inflammasome complex has emerged as an important component of
inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study …

Acute lung injury (ALI), known a severe disease along with high morbidity and mortality, is
lacking of specific therapies. Inflammation, apoptosis and oxidative stress are critical …