The abnormal deposition of proteins in and around neurons is a common pathological
feature of many neurodegenerative diseases. Among these pathological proteins, the …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with two major
hallmarks: extracellular amyloid plaques made of amyloid-β (Aβ) and intracellular …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

Growing evidence over the past decade has led to the realization that many sporadic and
familial neurodegenerative diseases are characterized by distinct hallmark brain lesions …

Tau is a brain microtubule-associated protein that directly binds to a microtubule and
dynamically regulates its structure and function. Under pathological conditions, tau self …

Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …

Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …