ACE2: the molecular doorway to SARS-CoV-2

MM Medina-Enríquez, S Lopez-León… - Cell & bioscience, 2020 - Springer
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …

Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

ACE2 Shedding and the Role in COVID-19

J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …

COVID-19 infection and circulating ACE2 levels: protective role in women and children

E Ciaglia, C Vecchione, AA Puca - Frontiers in pediatrics, 2020 - frontiersin.org
It has been reported that angiotensin-converting enzyme 2 (ACE2) is the main host cell
receptor of human pathogenic coronaviruses [severe acute respiratory syndrome …

ACE2: its potential role and regulation in severe acute respiratory syndrome and COVID‐19

M Rezaei, SA Ziai, S Fakhri… - Journal of cellular …, 2021 - Wiley Online Library
COVID‐19, a new disease caused by the 2019‐novel coronavirus (SARS‐CoV‐2), has
swept the world and challenged its culture, economy, and health infrastructure. Forced …

SARS-CoV-2 receptor is co-expressed with elements of the kinin–kallikrein, renin–angiotensin and coagulation systems in alveolar cells

D Sidarta-Oliveira, CP Jara, AJ Ferruzzi, MS Skaf… - Scientific reports, 2020 - nature.com
Abstract SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …

Advances in research on ACE2 as a receptor for 2019-nCoV

J Wu, W Deng, S Li, X Yang - Cellular and Molecular Life Sciences, 2021 - Springer
Currently, a novel coronavirus (SARS-CoV-2, also called 2019-nCoV) has triggered
pandemic Coronavirus Disease 2019 (COVID-19), an acute infectious respiratory disease …

[HTML][HTML] Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system

ML Yeung, JLL Teng, L Jia, C Zhang, C Huang, JP Cai… - Cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute
respiratory disease and multiorgan failure. Finding human host factors that are essential for …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

[HTML][HTML] SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

S Gross, C Jahn, S Cushman, C Baer… - Journal of molecular and …, 2020 - Elsevier
The current COVID-19 pandemic started several months ago and is still exponentially
growing in most parts of the world–this is the most recent and alarming update. COVID-19 …