Coronavirus disease 2019 (COVID-19) infection and renin angiotensin system blockers

C Bavishi, TM Maddox, FH Messerli - JAMA cardiology, 2020 - jamanetwork.com
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has already surpassed the combined mortality …

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

L Wu, Q Chen, K Liu, J Wang, P Han, Y Zhang, Y Hu… - Cell discovery, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
recent pandemic COVID-19, is reported to have originated from bats, with its intermediate …

Broad and differential animal angiotensin-converting enzyme 2 receptor usage by SARS-CoV-2

X Zhao, D Chen, R Szabla, M Zheng, G Li, P Du… - Journal of …, 2020 - Am Soc Microbiol
The COVID-19 pandemic has caused an unprecedented global public health and economic
crisis. The origin and emergence of its causal agent, SARS-CoV-2, in the human population …

ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

H Jia, X Yue, E Lazartigues - Nature communications, 2020 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry
receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

G Li, X He, L Zhang, Q Ran, J Wang, A Xiong… - Journal of …, 2020 - Elsevier
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human
cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of …

The possible dual role of the ACE2 receptor in asthma and coronavirus (SARS-CoV2) infection

ACCC Branco, MN Sato, RW Alberca - Frontiers in Cellular and …, 2020 - frontiersin.org
A new virus belonging to the coronaviridae family has been identified and named severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2)(Zhu et al., 2020). This virus can …

Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication

X Pang, Y Cui, Y Zhu - Acta Pharmacologica Sinica, 2020 - nature.com
Dear Editor, Since December 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused a pneumonia outbreak in Wuhan city, China, followed by global …

Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2

J Liu, F Lu, Y Chen, E Plow, J Qin - Journal of Biological Chemistry, 2022 - ASBMB
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is broadly accepted that SARS …

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou - Science, 2020 - science.org
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory
syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing …