A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance
K Sriram, PA Insel - British journal of pharmacology, 2020 - Wiley Online Library
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …
[HTML][HTML] ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in
Chinese people in December 2019 and has currently spread worldwide causing the COVID …
Chinese people in December 2019 and has currently spread worldwide causing the COVID …
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release
LI Labzin, KY Chew, K Eschke, X Wang, T Esposito… - Science …, 2023 - science.org
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on …
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on …
[HTML][HTML] A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient
B Nagy Jr, Z Fejes, Z Szentkereszty, R Sütő… - International Journal of …, 2021 - Elsevier
Endothelial cells express surface angiotensin-converting enzyme 2 (ACE2), the main
receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that promotes …
receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that promotes …
ACE2 (Angiotensin-Converting Enzyme 2) in cardiopulmonary diseases: ramifications for the control of SARS-CoV-2
Discovery of ACE2 (angiotensin-converting enzyme 2) revealed that the renin-angiotensin
system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly …
system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly …
Epithelial and Endothelial Expressions of ACE2: SARS-CoV-2 Entry Routes.
Angiotensin converting enzyme 2 (ACE2) is a main receptor for SARS-CoV-2 entry to the
host cell. ACE2 is one of the key enzymes in renin-angiotensin system and plays a vital role …
host cell. ACE2 is one of the key enzymes in renin-angiotensin system and plays a vital role …
The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin …
The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge
applicable to effectively combat the virus. Therefore, different scientific discovery strategies …
applicable to effectively combat the virus. Therefore, different scientific discovery strategies …
[HTML][HTML] ACE2 elevation in severe COVID-19
R Reindl-Schwaighofer, S Hödlmoser… - American journal of …, 2021 - atsjournals.org
Methods We measured enzymatically active plasma ACE2 concentration (subsequently
referred to as “ACE2”) and key RAS metabolites in 532 blood samples obtained from 126 …
referred to as “ACE2”) and key RAS metabolites in 532 blood samples obtained from 126 …
[HTML][HTML] Expression of ACE2, soluble ACE2, angiotensin I, angiotensin II and angiotensin-(1-7) is modulated in COVID-19 patients
The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic
coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the …
coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the …