Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in …
Background Using high-dimensional penalized regression we studied genome-wide DNA-
methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral …
methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral …
Penalized logistic regression for high-dimensional DNA methylation data with case-control studies
H Sun, S Wang - Bioinformatics, 2012 - academic.oup.com
Motivation: DNA methylation is a molecular modification of DNA that plays crucial roles in
regulation of gene expression. Particularly, CpG rich regions are frequently hypermethylated …
regulation of gene expression. Particularly, CpG rich regions are frequently hypermethylated …
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
S Reppe, TG Lien, YH Hsu, VT Gautvik, OK Olstad… - Epigenetics, 2017 - Taylor & Francis
ABSTRACT DNA methylation affects expression of associated genes and may contribute to
the missing genetic effects from genome-wide association studies of osteoporosis. To …
the missing genetic effects from genome-wide association studies of osteoporosis. To …
Mendelian randomization identifies CpG methylation sites with mediation effects for genetic influences on BMD in peripheral blood monocytes
Osteoporosis is mainly characterized by low bone mineral density (BMD) and is an
increasingly serious public health concern. DNA methylation is a major epigenetic …
increasingly serious public health concern. DNA methylation is a major epigenetic …
A novel computational strategy for DNA methylation imputation using mixture regression model (MRM)
Background DNA methylation is an important heritable epigenetic mark that plays a crucial
role in transcriptional regulation and the pathogenesis of various human disorders. The …
role in transcriptional regulation and the pathogenesis of various human disorders. The …
[HTML][HTML] Predicting gene expression using DNA methylation in three human populations
Background DNA methylation, an important epigenetic mark, is well known for its regulatory
role in gene expression, especially the negative correlation in the promoter region …
role in gene expression, especially the negative correlation in the promoter region …
New variable selection strategy for analysis of high-dimensional DNA methylation data
In genetic association studies, regularization methods are often used due to their
computational efficiency for analysis of high-dimensional genomic data. DNA methylation …
computational efficiency for analysis of high-dimensional genomic data. DNA methylation …
Correcting length-bias in gene set analysis for DNA methylation data
The enrichment analysis of pre-defined gene sets is a widely used tool to extract functional
information in association studies. However, traditional methods give biased results on …
information in association studies. However, traditional methods give biased results on …
Incorporating genetic networks into case-control association studies with high-dimensional DNA methylation data
Background In human genetic association studies with high-dimensional gene expression
data, it has been well known that statistical selection methods utilizing prior biological …
data, it has been well known that statistical selection methods utilizing prior biological …
Epigenome‐wide association of DNA methylation in whole blood with bone mineral density
Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …
density (BMD) may converge through the epigenome, providing a tool to better understand …