Effective inhibition of SARS-CoV-2 entry by heparin and enoxaparin derivatives
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a
pandemic of historic proportions and continues to spread globally, with enormous …
pandemic of historic proportions and continues to spread globally, with enormous …
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
On the selectivity of heparan sulfate recognition by SARS-CoV-2 spike glycoprotein
JE Chittum, NV Sankaranarayanan… - ACS Medicinal …, 2021 - ACS Publications
SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies
on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the …
on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the …
Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an
unprecedented global pandemic demanding the urgent development of therapeutic …
unprecedented global pandemic demanding the urgent development of therapeutic …
Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro
Dear Editor, COVID-19, caused by the SARS-CoV-2 virus, has now spread worldwide with
catastrophic human and economic impacts and currently has infected over 10 million people …
catastrophic human and economic impacts and currently has infected over 10 million people …
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin
CJ Mycroft-West, D Su, I Pagani… - Thrombosis and …, 2020 - thieme-connect.com
The dependence of development and homeostasis in animals on the interaction of hundreds
of extracellular regulatory proteins with the peri-and extracellular glycosaminoglycan …
of extracellular regulatory proteins with the peri-and extracellular glycosaminoglycan …
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans
M Bermejo‐Jambrina, J Eder, TM Kaptein… - The EMBO …, 2021 - embopress.org
The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2) and outbreaks of new variants highlight the need for preventive treatments. Here, we …
CoV‐2) and outbreaks of new variants highlight the need for preventive treatments. Here, we …
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for
COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2 …
COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2 …
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms
G Paiardi, S Richter, P Oreste, C Urbinati… - Journal of Biological …, 2022 - ASBMB
Heparin, a naturally occurring glycosaminoglycan, has been found to have antiviral activity
against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus …
against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus …
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