Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

DNA methylation and the machinery involved in epigenetic regulation are key elements in
the maintenance of cellular homeostasis. Epigenetic mechanisms are involved in embryonic …

Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

DNA methylation, chromatin structure, transcription, and cancer have traditionally been
studied as separate phenomena. Recent data provide now direct physical and functional …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …