DNA methylation is vital for proper chromatin structure and function in mammalian cells.
Genetic removal of the enzymes that catalyze DNA methylation results in defective …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

Epigenetics is the study of heritable and stable changes in gene expression that occur
through alterations in the chromosome rather than in the DNA sequence. Despite not directly …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the
three best-characterized covalent modifications associated with a repressed chromatin state …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Methylation patterns are the result of de novo methylation, demethylation, and the
maintenance of existing methylation. Although the existence and identity of an active …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …