Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

The nucleosome surface is covered with multiple modifications that are perpetuated by eight
different classes of enzymes. These enzymes modify specific target sites both on DNA and …

Epigenetics is the study of heritable changes in gene expression that are not mediated at the
DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include …

DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

In the past few years, there has been a nascent convergence of scientific understanding of
inherited human diseases with epigenetics. Identified epigenetic processes involved in …

Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a
condensed state linked to transcriptional repression (heterochromatin). These states are …

Epigenetic regulation of gene expression is a dynamic and reversible process with DNA
methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …