neuropathology of non‐tau frontotemporal lobar degeneration

M Neumann, IRA Mackenzie - Neuropathology and applied …, 2019 - Wiley Online Library
Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with
frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological …

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

IRA Mackenzie, M Neumann - Journal of neurochemistry, 2016 - Wiley Online Library
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The past decade has seen the discovery of several new FTD‐causing genetic …

[HTML][HTML] Neuropathological background of phenotypical variability in frontotemporal dementia

KA Josephs, JR Hodges, JS Snowden… - Acta …, 2011 - Springer
Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a
heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have …

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43

IRA Mackenzie, M Neumann, NJ Cairns… - Journal of Molecular …, 2011 - Springer
Most cases of frontotemporal lobar degeneration (FTLD) are characterized by the abnormal
accumulation of either the microtubule-associated protein tau or the transactive response …

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

DJ Irwin, NJ Cairns, M Grossman, CT McMillan… - Acta …, 2015 - Springer
Frontotemporal lobar degeneration (FTLD) comprises two main classes of
neurodegenerative diseases characterized by neuronal/glial proteinaceous inclusions (ie …

Frontotemporal lobar degeneration: current concepts in the light of recent advances

S Kumar‐Singh, C Van Broeckhoven - Brain pathology, 2007 - Wiley Online Library
Work done over the past decade has led to a molecular understanding of frontotemporal
lobar degeneration (FTLD), a deadly disease that afflicts patients in mid‐life. It is a common …

[HTML][HTML] Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

IRA Mackenzie, M Neumann, EH Bigio, NJ Cairns… - Acta …, 2010 - Springer
One year ago, in this journal, we published a recommended nomenclature for the
neuropathologic subtypes of frontotemporal lobar degeneration (FTLD)[7]. A major impetus …

Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management

RE Seltman, BR Matthews - CNS drugs, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) describes a spectrum of clinically, pathologically
and genetically heterogeneous neurodegenerative disorders of unknown aetiology. FTLD …

The molecular basis of frontotemporal dementia

M Neumann, M Tolnay, IRA Mackenzie - Expert reviews in molecular …, 2009 - cambridge.org
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Familial FTD has been linked to mutations in several genes, including those encoding …

Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …