Objectives This study sought to evaluate the frequency and prognostic implications of urgent
heart failure (HF) visits in a large global clinical trial of HF with preserved ejection fraction …

Background The period shortly after hospitalization for heart failure (HF) represents a high-
risk window for recurrent clinical events, including rehospitalization or death. Objectives This …

Heart failure with preserved ejection fraction is a highly morbid condition with few proven
treatment options. The PARAGON-HF study (Prospective Comparison of ARNI with ARB …

Background—Many episodes of worsening of heart failure (HF) are treated by increasing
oral therapy or temporary intravenous treatment in the community or emergency department …

Abstract Aims The PARAGLIDE-HF trial demonstrated reductions in natriuretic peptides with
sacubitril/valsartan compared with valsartan in patients with heart failure (HF) with mildly …

Background—Hospitalization for acute heart failure (HF) is associated with high rates of
subsequent mortality and readmission. We assessed the influence of the time interval …

Objectives This study investigated the prognostic importance of heart failure (HF) signs and
symptoms in patients with heart failure and preserved ejection fraction (HFpEF), and the …

Background: To describe the baseline characteristics of patients with heart failure and
preserved left ventricular ejection fraction enrolled in the PARAGON-HF trial (Prospective …

Abstract Background The PARAGON-HF trial studied the effect of sacubitril/valsartan
(Sac/Val) compared with valsartan (Val) on clinical outcomes in patients with chronic heart …

Aims As sacubitril/valsartan may potentiate early natriuresis, expert consensus documents
recommend diuretic dose reduction on first initiation. However, there are limited data on the …