New multi-component solid forms of anti-cancer drug Erlotinib: Role of auxiliary interactions in determining a preferred conformation

P Sanphui, L Rajput, SP Gopi… - … Section B: Structural …, 2016 - scripts.iucr.org
Erlotinib is a BCS (biopharmaceutical classification system) class II drug used for the
treatment of non-small cell lung cancer. There is an urgent need to obtain new solid forms of …

Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies

SH Thorat, CP George, PS Shaligram, PR Suresha… - …, 2021 - pubs.rsc.org
Erlotinib, a non-small cell lung cancer BCS class II drug, was found to occur as two
polymorphs and two hydrates depending on the crystallization conditions. The monohydrate …

Multicomponent crystals of erlotinib

B Sridhar, K Ravikumar, H Krishnan… - … Section C: Crystal …, 2010 - scripts.iucr.org
Erlotinib [systematic name: N-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy) quinazolin-4-
amine], a small-molecule epidermal growth factor receptor inhibitor, useful for the treatment …

Polymorphism in Erlotinib Hydrochloride: New Insights into Relative Stability, Thermal Behavior, and Structural Differences of Forms A and B

CT António, AOL Évora, CES Bernardes… - Crystal Growth & …, 2023 - ACS Publications
Erlotinib hydrochloride (EtbHCl), whose polymorphism is still ill-characterized, is an
essential component of the current armamentarium for the treatment of pancreatic and lung …

[HTML][HTML] Erlotinib hydrochloride: an anticancer agent

S Selvanayagam, B Sridhar… - … Section E: Structure …, 2008 - scripts.iucr.org
In the cation of the title compound, C22H24N3O4+· Cl−, an active ingredient of the
anticancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 …

Exploring a solvated dimer of Gefitinib: a quantitative analysis

D Angira, A Shaik, S Kirubakaran… - … Section C: Structural …, 2018 - scripts.iucr.org
Gefitinib or Iressa is an orally administered anilinoquinazoline used in cancer chemotherapy
for the treatment of lung and breast cancer. It is reported to exist in two polymorphic forms, a …

New cocrystals of ezetimibe with L-proline and imidazole

MR Shimpi, SL Childs, D Boström, SP Velaga - CrystEngComm, 2014 - pubs.rsc.org
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug
ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic …

Three Polymorphs and Two Hydrates of a Multidrug Crystal Involving Gefitinib and Rhein: Characterization, Stability, and Solubility Aspects

F Zhang, XT Long, BY Ren, XL Dai, TB Lu… - Crystal Growth & …, 2024 - ACS Publications
Multidrug crystals, comprising multiple drugs in the same crystal lattice, can be used to
develop drug combinations with improved physicochemical properties. The investigation on …

Pharmaceutical cocrystals of ethenzamide: structural, solubility and dissolution studies

S Aitipamula, ABH Wong, PS Chow, RBH Tan - CrystEngComm, 2012 - pubs.rsc.org
Pharmaceutical cocrystals involving an analgesic drug, ethenzamide (EA) and coformers,
such as salicylic acid (SA), 2-chloro-4-nitrobenzoic acid (CNBA), vanillic acid (VA), 4 …

Molecular conformation and crystallization: The case of ethenzamide

KR Back, RJ Davey, T Grecu, CA Hunter… - Crystal growth & …, 2012 - ACS Publications
Ethenzamide is a small, conformationally labile pharmaceutical molecule which crystallizes
in an unusual conformation relative to both its co-crystals and to similar molecules found in …