New multi-component solid forms of anti-cancer drug Erlotinib: Role of auxiliary interactions in determining a preferred conformation
Erlotinib is a BCS (biopharmaceutical classification system) class II drug used for the
treatment of non-small cell lung cancer. There is an urgent need to obtain new solid forms of …
treatment of non-small cell lung cancer. There is an urgent need to obtain new solid forms of …
Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies
SH Thorat, CP George, PS Shaligram, PR Suresha… - …, 2021 - pubs.rsc.org
Erlotinib, a non-small cell lung cancer BCS class II drug, was found to occur as two
polymorphs and two hydrates depending on the crystallization conditions. The monohydrate …
polymorphs and two hydrates depending on the crystallization conditions. The monohydrate …
Multicomponent crystals of erlotinib
B Sridhar, K Ravikumar, H Krishnan… - … Section C: Crystal …, 2010 - scripts.iucr.org
Erlotinib [systematic name: N-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy) quinazolin-4-
amine], a small-molecule epidermal growth factor receptor inhibitor, useful for the treatment …
amine], a small-molecule epidermal growth factor receptor inhibitor, useful for the treatment …
Polymorphism in Erlotinib Hydrochloride: New Insights into Relative Stability, Thermal Behavior, and Structural Differences of Forms A and B
CT António, AOL Évora, CES Bernardes… - Crystal Growth & …, 2023 - ACS Publications
Erlotinib hydrochloride (EtbHCl), whose polymorphism is still ill-characterized, is an
essential component of the current armamentarium for the treatment of pancreatic and lung …
essential component of the current armamentarium for the treatment of pancreatic and lung …
[HTML][HTML] Erlotinib hydrochloride: an anticancer agent
S Selvanayagam, B Sridhar… - … Section E: Structure …, 2008 - scripts.iucr.org
In the cation of the title compound, C22H24N3O4+· Cl−, an active ingredient of the
anticancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 …
anticancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 …
Exploring a solvated dimer of Gefitinib: a quantitative analysis
Gefitinib or Iressa is an orally administered anilinoquinazoline used in cancer chemotherapy
for the treatment of lung and breast cancer. It is reported to exist in two polymorphic forms, a …
for the treatment of lung and breast cancer. It is reported to exist in two polymorphic forms, a …
New cocrystals of ezetimibe with L-proline and imidazole
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug
ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic …
ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic …
Three Polymorphs and Two Hydrates of a Multidrug Crystal Involving Gefitinib and Rhein: Characterization, Stability, and Solubility Aspects
F Zhang, XT Long, BY Ren, XL Dai, TB Lu… - Crystal Growth & …, 2024 - ACS Publications
Multidrug crystals, comprising multiple drugs in the same crystal lattice, can be used to
develop drug combinations with improved physicochemical properties. The investigation on …
develop drug combinations with improved physicochemical properties. The investigation on …
Pharmaceutical cocrystals of ethenzamide: structural, solubility and dissolution studies
Pharmaceutical cocrystals involving an analgesic drug, ethenzamide (EA) and coformers,
such as salicylic acid (SA), 2-chloro-4-nitrobenzoic acid (CNBA), vanillic acid (VA), 4 …
such as salicylic acid (SA), 2-chloro-4-nitrobenzoic acid (CNBA), vanillic acid (VA), 4 …
Molecular conformation and crystallization: The case of ethenzamide
Ethenzamide is a small, conformationally labile pharmaceutical molecule which crystallizes
in an unusual conformation relative to both its co-crystals and to similar molecules found in …
in an unusual conformation relative to both its co-crystals and to similar molecules found in …