Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies

O Kutkat, Y Moatasim, AA Al‐Karmalawy… - Scientific Reports, 2022 - nature.com
During the current coronavirus disease 2019 (COVID-19) pandemic, symptoms of
depression are commonly documented among both symptomatic and asymptomatic …

Combination therapy with fluoxetine and the nucleoside analog GS-441524 exerts synergistic antiviral effects against different SARS-CoV-2 variants in vitro

L Brunotte, S Zheng, A Mecate-Zambrano, J Tang… - Pharmaceutics, 2021 - mdpi.com
The ongoing SARS-CoV-2 pandemic requires efficient and safe antiviral treatment
strategies. Drug repurposing represents a fast and low-cost approach to the development of …

Fluoxetine can inhibit SARS-CoV-2 in vitro

A Dechaumes, MP Nekoua, S Belouzard, F Sane… - Microorganisms, 2021 - mdpi.com
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in
the coronavirus disease pandemic, drastically affecting global health and economy. Though …

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2

M Zimniak, L Kirschner, H Hilpert, J Seibel, J Bodem - BioRxiv, 2020 - biorxiv.org
To circumvent time-consuming clinical trials, testing whether existing drugs are effective
inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this …

Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

Y Pashaei - Journal of Clinical Neuroscience, 2021 - Elsevier
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is
undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 …

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

M Zimniak, L Kirschner, H Hilpert, N Geiger, O Danov… - Scientific reports, 2021 - nature.com
To circumvent time-consuming clinical trials, testing whether existing drugs are effective
inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this …

Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use

VS Foletto, TF Da Rosa, MB Serafin… - European journal of clinical …, 2022 - Springer
Purpose The absence of specific treatments for COVID-19 leads to an intense global effort in
the search for new therapeutic interventions and better clinical outcomes for patients. This …

Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19

M Mahdi, L Hermán, JM Réthelyi, BL Bálint - International Journal of …, 2022 - mdpi.com
Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

Antidepressant drugs and COVID-19: A review of basic and clinical evidence

M Mas, JA García-Vicente, A Estrada-Gelonch… - Journal of clinical …, 2022 - mdpi.com
The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter
development strategy in order to support clinicians with this difficult therapeutic dilemma …