Transcription factor GATA 2 is highly expressed in hematopoietic stem cells and progenitors,
whereas its expression declines after erythroid commitment of progenitors. In contrast, the …

Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis …

GATA transcription factor family members GATA1 and GATA2 play crucial roles in the
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …

Transcription factor GATA-1 plays an important role in gene regulation during the
development of erythroid cells. Several reports suggest that GATA-1 plays multiple roles in …

Abstract Three Gata transcription factors (Gata1,-2, and-3) are essential for hematopoiesis.
These factors are thought to play distinct roles because they do not functionally replace each …

GATA‐1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and
mast cell lineages. It acts as an activator and repressor of different target genes, for example …

The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during
erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the …

Interplay among GATA transcription factors is an important determinant of cell fate during
hematopoiesis. Although GATA-2 regulates hematopoietic stem cell function, mechanisms …

Transcription factor GATA-1 is essential for the development of the erythroid lineage. To
ascertain whether strict control of GATA-1 expression level is necessary for achieving proper …

Although the formation of terminally differentiated erythroid cells has been shown to require
the presence of a functional GATA-1 gene in vivo, the role of this transcription factor and …