The imaging genetics approach to studying the genetic basis of disease leverages the
individual strengths of both neuroimaging and genetic studies by visualizing and quantifying …

Background: Genome-wide association studies (GWASs) are increasingly used to identify
risk genes for complex illnesses including schizophrenia. These studies may require …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Current diagnoses of schizophrenia and related psychiatric disorders are classified by
phenomenological principles and clinical descriptions while ruling out other symptoms and …

Cognitive impairment is a prominent and debilitating feature of schizophrenia. Genetic
predisposition likely accounts for a large proportion of these cognitive deficits. Direct …

Schizophrenia has complex genetic heritability. It is also genetically heterogeneous. To the
extent that genes are associated with symptom constellations in schizophrenia, they do so …

Multiple neurotransmitter circuits are disturbed in schizophrenia, and the dopamine
hypothesis of schizophrenia prevails as the hypothesis with most empirical support. On the …

Recently, deriving candidate endophenotypes from brain imaging data has become a
valuable approach to study genetic influences on schizophrenia (SZ), whose …

Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …

A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …