Parthenolide displaces [3H] ketanserin from 5HT2A receptors from rat and rabbit brain and
cloned 5HT2A receptors. K i's are in the 100− 250 μM range. These results suggest that …

Mutations producing constitutively active G-protein coupled receptors have been found in
the pathophysiology of several diseases, implying that inverse agonists at the constitutively …

This study investigated the binding affinities of a newly synthesized 5-HT2 antagonist, AT-
1015 (N-[2-[4-(5H-dibenzo [a, d] cyclohepten-5-ylidene)-piperidino] ethyl]-1-formyl-4 …

N-Methyllaurotetanine (1) has been reported to display good affinity for the 5-HT1A receptor,
but no structure–affinity studies have been performed to date. The commercially available …

The cAMP response of the 5-HT1D receptor antagonist GR 127,935 was compared with 5-
CT and ketanserin at cloned human 5-HT1Dα receptor sites in transfected C6-glial cells. GR …

The antagonist effects of ketanserin and 2′-methyl-4′-(5-methyl-1, 2, 4) oxadiazol-3-yl)-
biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR …

On the basis of an earlier finding that 5-methyl-5 H-1, 2, 3, 4-tetrahydropyrido [4, 3-b] indole
(5-methyl-1, 2, 3, 4-tetrahydro-γ-carboline; 1) binds at murine 5-HT5A receptors, preliminary …

The antagonistic properties of DAU 6285, an azabicycloalkyl benzimidazolone derivative, at
putative 5-hydroxytryptamine 4 (5-HT 4) receptors were investigated in in vitro preparations …

LY53857 is a potent antagonist at vascular 5HT2 receptors that lacks prominent α1 or
dopamine antagonist activity. The present report investigates the interaction of LY53857 with …

Tegaserod (Zelnorm®) is a potent 5‐hydroxytryptamine4 (5‐HT4) receptor agonist with
clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The …