New insights into benzo [⍺] pyrene osteotoxicity in zebrafish

M Tarasco, PJ Gavaia, A Bensimon-Brito… - Ecotoxicology and …, 2021 - Elsevier
Persistent and ubiquitous organic pollutants, such as the polycyclic aromatic hydrocarbon
benzo [⍺] pyrene (BaP), represent a major threat to aquatic organisms and human health …

Insight into the transgenerational effect of benzo [a] pyrene on bone formation in a teleost fish (Oryzias latipes)

F Seemann, DR Peterson, PE Witten, BS Guo… - … and Physiology Part C …, 2015 - Elsevier
Recent cross-generational studies in teleost fish have raised the awareness that high levels
of benzo [a] pyrene (BaP) could affect skeletal integrity in the directly exposed F0 and their …

Ancestral benzo [a] pyrene exposure affects bone integrity in F3 adult fish (Oryzias latipes)

F Seemann, CB Jeong, G Zhang, MT Wan, B Guo… - Aquatic Toxicology, 2017 - Elsevier
Abstract Benzo [a] pyrene (BaP) at an environmentally relevant concentration (1 μg/L) has
previously been shown to affect bone development in a transgenerational manner in F3 …

Benzo(a)pyrene reduces osteoclast and osteoblast activity in ex‐vivo scales of zebrafish (Danio rerio [Hamilton‐Buchanan, 1822]) and goldfish (Carassius auratus …

I Torvanger, JR Metz, PA Olsvik… - Journal of Applied …, 2018 - Wiley Online Library
Environmental contaminants have previously been demonstrated to cause bone deformities
mediated through the aryl hydrocarbon receptor (AhR) in fish and mammals. Polycyclic …

Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo [a] pyrene exposure: Cellular and transcriptomic insights

J Mo, MT Wan, DWT Au, J Shi, N Tam, X Qin… - Journal of …, 2023 - Elsevier
Abstract Benzo [a] pyrene (BaP), a ubiquitous pollutant, raises environmental health
concerns due to induction of bone toxicity in the unexposed offspring. Exposure of F0 …

Multigenerational Impacts of Benzo[a]pyrene on Bone Modeling and Remodeling in Medaka (Oryzias latipes)

J Mo, DWT Au, MT Wan, J Shi, G Zhang… - … science & technology, 2020 - ACS Publications
Ancestral benzo [a] pyrene (BaP)(1 μg/L, 21 days) exposure has previously been shown to
cause skeletal deformities in medaka (Oryzias latipes) larvae in the F1–F3 generation …

Benzo [a] pyrene osteotoxicity and the regulatory roles of genetic and epigenetic factors: A review

J Mo, DWT Au, J Guo, C Winkler… - Critical Reviews in …, 2022 - Taylor & Francis
As a ubiquitous environmental pollutant, benzo [a] pyrene (BaP) has been extensively
studied for over 80 years. While much research has focused on its genotoxic and …

The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo [a] pyrene exposed F1 and F3 male medaka

T Wan, J Mo, DWT Au, X Qin, NYK Tam, RYC Kong… - Epigenetics, 2023 - Taylor & Francis
ABSTRACT Benzo [a] pyrene (BaP) is ubiquitously present in the aquatic environment and
has been identified as a bone toxicant. Previous studies have demonstrated that ancestral …

[HTML][HTML] Long-term BPA exposure leads to bone malformation and abnormal expression of MAPK/Wnt/FoxO signaling pathway genes in zebrafish offspring

Z Zhu, J Wang, Q Cao, S Liu, W Wei, H Yang… - Ecotoxicology and …, 2022 - Elsevier
Bisphenol A (BPA) is one of the world's most widely used plasticizer, and its hazardous
impacts have been well studied. However, few studies focused on the effects of parental …

miR-21 is involved in skeletal deficiencies of zebrafish embryos exposed to polychlorinated biphenyls

L Ju, Z Zhou, B Jiang, Y Lou, Z Zhang - Environmental Science and …, 2017 - Springer
Polychlorinated biphenyl (PCB) exposure increases the incidence and severity of skeletal
diseases, but little is known about the mechanisms that mediate this relationship. We …