Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel

B Xie, YY Lu, ZH Luo, Z Qu, CG Zheng… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Marsdenia tenacissima (Roxb.) Wight et Arn is a
vine distributed in southwest area of China and used in folk medicine for treatment of tumors …

γ-Carbolines: binding at 5-HT5A serotonin receptors

N Khorana, A Purohit, K Herrick-Davis, M Teitler… - Bioorganic & Medicinal …, 2003 - Elsevier
Screening of various agents resulted in the identification of 5-methyl-1, 2, 3, 4-tetrahydro-γ-
carboline (1; Ki= 5,300 nM) as a compound with modest affinity for mouse 5-HT5A receptors …

The structure and synthesis of C19-diterpenoid alkaloids

SW Pelletier, NV Mody - The alkaloids: chemistry and physiology, 1979 - Elsevier
Publisher Summary Since the early 1800s, the alkaloids (nitrogenous organic bases)
isolated from plants of the Delphinium and Aconitum genera (Ranunculaceae) and more …

Trijuganone A and B: two new phenanthrenequinones from roots of Salvia trijuga

L Xuezhao, L Houwei, N Masatake - Planta medica, 1990 - thieme-connect.com
Trijuganone A and B: Two New Phenanthrenequinones from Roots of Salvia trijuga Page 1
Planta Medica 56(1990) 87 Trijuganone A and B: Two New Phenanthrenequinones from Roots …

New potent 5-HT2A receptor ligands containing an N′-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation

F Fiorino, B Severino, E Magli, E Perissutti… - European journal of …, 2012 - Elsevier
N′-cyanopicolinamidine derivatives, linked to an arylpiperazine moiety, were prepared and
their affinity to serotonin 5-HT1A, 5-HT2A and 5-HT2C receptors were evaluated. The …

Salicassin, an Unprecedented ChalconeDiterpene Adduct and a Quinone Methide Triterpenoid from Maytenus salicifolia

CG Magalhaes, GD de Fátima Silva… - Helvetica Chimica …, 2013 - Wiley Online Library
In continuation of our work on Maytenus salicifolia, we report herein the isolation and
structural elucidation of two new compounds, salicassin (1), a diterpene‐chalcone adduct …

Antinociceptive effect of 7-hydroxy-3, 4-dihydrocadalin isolated from Heterotheca inuloides: role of peripheral 5-HT1 serotonergic receptors

HI Rocha-González, E Blaisdell-López… - European journal of …, 2010 - Elsevier
The purpose of this study was to investigate the possible antinociceptive effect of
Heterotheca inuloides in inflammatory pain and to identify the main compounds involved in …

Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata

C Lei, LB Zhang, J Yang, LX Gao, JY Li, J Li, AJ Hou - Tetrahedron Letters, 2016 - Elsevier
Abstract Macdentichalcone (1), an unprecedented polycyclic dimeric chalcone featuring a
unique quinonoid moiety, was isolated from Macaranga denticulata, together with 1-(5, 7 …

Highly oxygenated grayanane diterpenoids with structural diversity from the flowers of Rhododendron dauricum and their analgesic activities

Y Feng, H Zhang, B Gao, G Zheng, S Zha, G Yao - Bioorganic Chemistry, 2023 - Elsevier
Abstract Twenty-eight grayanane diterpenoids (1–28) including 13 new ones, named
daublossomins A–M (1–13), and two new natural products, 3-O-acetylgrayanotoxin II (14) …

A UPLC-ESI-Q-TOF method for rapid and reliable identification and quantification of major indole alkaloids in Catharanthus roseus

WT Jeong, HB Lim - Journal of Chromatography B, 2018 - Elsevier
We developed a novel ultra performance liquid chromatography-quadrupole time-of-flight
(UPLC-Q-TOF) mass spectrometry method that allows sensitive, rapid, and reliable detection …