The DNA mismatch repair protein, MutS, is a dimeric protein that recognizes mismatched
bases and has an intrinsic ATPase activity. Here, a series of Taq MutS proteins having C …

Spontaneous mutation levels are kept low in most organisms by a variety of error-reducing
mechanisms, some of which ensure a high level of fidelity during DNA replication. The mutT …

The ability of related DNAs to undergo recombination decreases with increased sequence
divergence. Mismatch repair has been proposed to be a key factor in preventing …

The kinetics of mutator sweeps was followed in two independent populations of Escherichia
coli grown for up to 350 generations in glucose-limited continuous culture. A rapid elevation …

The Escherichia coli mutL gene product has been purified to near homogeneity from an
overproducing clone. The mutL locus encodes a polypeptide of 70,000 daltons as …

MutS and its homologues are highly conserved proteins which, with MutH and MutL repair
DNA mismatches (1). The MutS protein binds to heteroduplex DNA at the site of mismatch …

Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC→ TA
transversion mutation in stationary-phase and exponentially growing bacteria and in mutY …

MutS is the key protein of the Escherichia coli DNA mismatch repair system. It recognizes
mispaired and unpaired bases and has intrinsic ATPase activity. ATP binding after mismatch …

DNA mismatch repair (MMR) repairs mispaired bases in DNA generated by replication
errors. MutS or MutS homologs recognize mispairs and coordinate with MutL or MutL …

The mutator phenotype has been linked in several bacterial genera to a defect in the methyl-
mismatch repair system, in which the major components are MutS and MutL. This system is …