DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …

Initiation and progression of human caner not only depends on genetic alterations but also
on epigenetic changes such as DNA methylation and histone modifications. Aberrant DNA …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …

In multicellular organisms, all the cells are genetically identical but turn genes on or off at the
right time to promote differentiation into specific cell types. The regulation of higher-order …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …