The role of DNA methylation and recently discovered hydroxymethylation in the function of
the human epigenome is currently one of the hottest topics in the life sciences. Progress in …

Methylation of the cytosine base in DNA, DNA methylation, is an essential epigenetic mark
in mammals that contributes to the regulation of transcription. Several advances have been …

DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

Epigenetic regulation in eukaryotic and mammalian systems is a complex and emerging
field of study. While histone modifications create an open chromatin conformation allowing …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

Next year will mark 60 years since Dr. Leslie Foulds outlined his hypothesis that cancer is “a
dynamic process advancing through stages that are qualitatively different,” leading the way …

The epigenome, which comprises chromatin, associated proteins, and the pattern of
covalent modification of DNA by methylation, sets up and maintains gene expression …