Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-
based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future …

Epigenetic mechanisms comprising DNA methylation, histone modifications, and noncoding
RNAs affect chromatin structure and regulate gene expression. These mechanisms control …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation at near base pair level …

Epigenetic mechanisms including DNA and histone modifications result in silencing of
genes without changing the coding sequence of the gene. Even though these events are …

DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …