Circulating cytokines reflect the expression of pro-inflammatory cytokines in atherosclerotic plaques

A Edsfeldt, H Grufman, G Asciutto, M Nitulescu… - Atherosclerosis, 2015 - Elsevier
Aims Inflammation is a key factor in the development of plaque rupture and acute
cardiovascular events. Although imaging techniques can be used to identify vulnerable …

Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis

E Ammirati, F Moroni, GD Norata… - Mediators of …, 2015 - Wiley Online Library
Atherosclerosis is the focal expression of a systemic disease affecting medium‐and large‐
sized arteries, in which traditional cardiovascular risk factor and immune factors play a key …

[HTML][HTML] Inflammatory biomarkers in atherosclerosis: pentraxin 3 can become a novel marker of plaque vulnerability

A Shindo, H Tanemura, K Yata, K Hamada, M Shibata… - PloS one, 2014 - journals.plos.org
Inflammation is crucially involved in the development of carotid plaques. We examined the
relationship between plaque vulnerability and inflammatory biomarkers using intraoperative …

[HTML][HTML] Inflammation of carotid plaques and risk of cerebrovascular events

P Poredos, ID Gregoric, MK Jezovnik - Annals of Translational …, 2020 - ncbi.nlm.nih.gov
Carotid atherosclerotic plaques represent a risk for ischemic stroke. The data indicate that
the risk for distal embolization from atherosclerotic lesions in internal carotid arteries is not …

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

J Frostegård, AK Ulfgren, P Nyberg, U Hedin… - Atherosclerosis, 1999 - Elsevier
The atherosclerotic lesion contains large numbers of macrophages and T lymphocytes. This
suggests that a cellular immune response may take place in the lesion, and oxidized …

Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients

H Grufman, A Schiopu, A Edsfeldt, H Björkbacka… - Atherosclerosis, 2014 - Elsevier
Objective Most acute cardiovascular events are caused by rupture of an atherosclerotic
plaque. The incidence of cardiovascular events increases with age and inflammation is …

Circulating markers of inflammation and atherosclerosis

L Lind - Atherosclerosis, 2003 - Elsevier
Atherosclerosis is nowadays generally accepted as an inflammatory disease. It is known that
local inflammation occurs in the formation the plaques, as macrophages and other immuno …

Patients with an inflamed atherosclerotic plaque have increased levels of circulating inflammatory markers

P Poredos, A Spirkoska, L Lezaic… - … of Atherosclerosis and …, 2017 - jstage.jst.go.jp
Aim: Inflammation is highlighted in the pathogenesis and destabilization of atherosclerotic
lesions. Noninvasive identification of inflammation of atherosclerotic lesions has been …

Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke

F Montecucco, S Lenglet, A Gayet-Ageron, M Bertolotto… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—The concept of “vulnerable plaque” has been extended to the
more recent definition of the “cardiovascular vulnerable patient,” in which “intraplaque” and …

Inflammation of the atherosclerotic cap and shoulder of the plaque is a common and locally observed feature in unruptured plaques of femoral and coronary arteries

G Pasterkamp, AH Schoneveld… - … , and vascular biology, 1999 - Am Heart Assoc
Retrospectively, plaque rupture is often colocalized with inflammation of the cap and
shoulder of the atherosclerotic plaque. Local inflammation is therefore considered a …