Objectives The physiological effects of polymorphisms of the renin–angiotensin—
aldosterone system (RAAS) are poorly understood. Long-term effects of genetic variants can …

Background—Previous studies reported an association of the 1166 A/C polymorphism of the
angiotensin II (Ang II) type 1 receptor gene with high blood pressure and cardiovascular …

Several investigations have shown heterogeneity in the functional responses to angiotensin
II (Ang II) in patients with essential hypertension. The present study was initiated to evaluate …

An adenine/cytosine (A/C) base substitution at position 1166 in the angiotensin II type 1
receptor (AT1R) gene is associated with the incidence of essential hypertension and …

Many studies have attempted to relate genetic variants of components of the renin-
angiotensin system to complex diseases such as essential hypertension, cardiovascular …

Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and
angiotensin II. Background Most of the known actions of angiotensin II (Ang II) are mediated …

Angiotensin II type 1 (AT1) receptor mediates the vasoconstriction and growth-promoting
effect of angiotensin II in humans. It has been reported that a polymorphism of the AT1 …

Objective Clinical observations point towards heterogeneity in patients' responses to
antihypertensive drugs. As our earlier work showed that angiotensin II (AngII) sensitivity is …

The renin‐angiotensin system is involved in control of blood pressure and salt and fluid
homeostasis. Genes for components of this system have been of major focus in research on …

Considerable progress in our understanding of the role of the angiotensin II type 2 (AT2)
receptor in the development of cardiac hypertrophy and coronary artery disease has been …