We had previously demonstrated that phlorotannins, which are marine polyphenols,
enhance sleep in mice via the GABAA-benzodiazepine (BZD) receptor. Among the …

Rationale In psychopharmacology, researchers have been interested in the hypnotic effects
of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant …

In our previous studies, we have demonstrated that marine polyphenol phlorotannins
promote sleep through the benzodiazepine site of the gamma-aminobutyric acid type A …

In our previous studies, a standardized phlorotannin (brown seaweed polyphenol)
supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid …

Sleep is vital for maintaining health and well-being; however, insomnia is currently a
widespread health complaint. According to a report from the National Sleep Foundation in …

Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity
as alternatives to prescription drugs for improving sleep. Recently, numerous studies have …

The primary objective was to investigate whether seaweeds have hypnotic activity. Methanol
extracts of 30 seaweeds were screened for their binding activity at the GABA type A …

α-Pinene is a major monoterpene of the pine tree essential oils. It has been reported that α-
pinene shows anxiolytic and hypnotic effects upon inhaled administration. However …

The sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines,
are the most common treatments for insomnia. However, concerns regarding patterns of …

Dexmedetomidine, a highly selective α2-adrenergic agonist, is widely used in clinical
anesthesia and ICU sedation. Recent studies have found that dexmedetomidine-induced …