Epigenetic mechanisms including DNA and histone modifications result in silencing of
genes without changing the coding sequence of the gene. Even though these events are …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

Epigenetic events have been associated with virtually every step of tumor development and
progression, and epigenetic alterations are believed to occur early in tumor development …

The classical theory of recessive oncogenesis predicted a mutational mechanism for the
inactivation of tumor suppressor (TS) genes. This prediction has been amply confirmed, but …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …

Epigenetic silencing of gene transcription by methylation of DNA or modification of histones
is a key event in neoplastic initiation and progression. Alterations of the epigenome have …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …