Atherosclerosis is a chronic inflammatory process and both the innate and adaptive immune
systems 1 play central roles in its initiation and subsequent progression. 2 Experimental …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Despite considerable advances in reducing the global burden of atherosclerotic
cardiovascular disease by targeting conventional risk factors, significant residual risk …

Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

It is now generally recognized that atherosclerosis is a chronic inflammatory disease,
characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of …

The concept of the involvement of inflammation in the pathogenesis of atherosclerosis has
existed since the 1800s, stemming from sentinel pathologic observations made by Rudolf …

Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein
entry, retention, and oxidative modification cause endothelial damage, triggering innate and …

Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This
review highlights key concepts in our current understanding of the role of inflammation in the …

Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …