Inteins are self-splicing intervening sequences in proteins, and inteins of pathogenic
organisms can be attractive drug targets. Here, we report an intein in important fungal …

Inteins are intervening sequences that are transcribed and translated with flanking host
protein sequences and then self-excised by protein splicing. Bi-functional inteins also …

Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …

Inteins are protein-intervening sequences found inside the coding region of different host
proteins and are translated in-frame with them. They can self-excise through protein splicing …

Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …

As the Cne PRP8 intein is active and exists in an essential gene of an important fungal
pathogen, inhibitors of splicing and assays for intein activity are of interest. The self-splicing …

Inteins (internal proteins) are mobile genetic elements, inserted in housekeeping proteins,
with self-splicing properties. Some of these elements have been recently pointed out as …

Background We recently described a mini-intein in the PRP8 gene of a strain of the
basidiomycete Cryptococcus neoformans, an important fungal pathogen of humans. This …

Inteins or" internal proteins" are coding sequences that are transcribed and translated with
flanking sequences (exteins). After translation, the inteins are excised by an autocatalytic …

Inteins are internal protein domains found inside the coding region of different proteins. They
can autocatalytically self-excise from their host protein and ligate the protein flanks, called …