The parallel expression of activation products of the coagulation, fibrinolysis, and
complement systems has long been observed in both clinical and experimental settings …

Complement and coagulation are evolutionarily related proteolytic cascades in the blood
that are critical for effecting an appropriate innate response to injury that limits bleeding and …

The convergence between complement and the clotting system extends far beyond the
chemical nature of the complement and coagulation components, both of which form …

The complement system, originally classified as part of innate immunity, is a tightly self-
regulated system consisting of liquid phase, cell surface, and intracellular proteins. In the …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

The coagulation and complement systems are ancestrally related enzymatic cascades of the
blood. Although their primary purposes have diverged over the past few hundred million …

A mutual relationship exists between immune activation and mechanisms of thrombus
formation. In particular, elements of the innate immune response such as the complement …

In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

Coagulation and innate immunity are linked evolutionary processes that orchestrate the host
defence against invading pathogens and injury. The complement system is integral to innate …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …