We studied the bioactivity of vancomycin and tobramycin eluted from methylmethacrylate
bone cement. Aliquots of the drainage were obtained at 1, 6, 12 and 24 hours following total …

Bacterial infection of bone prosthesis is presumed to occur through contamination during the
operation despite prophylaxis and can also develop as a result of haematogenous spread …

A prospective in vivo quantification was performed to measure the elution of tobramycin and
vancomycin antibiotics from two commonly used bone cements. Forty patients were divided …

The increase in resistance rates to antibiotics of bacteria isolated from infected hip joints,
particularly staphylococci, prompted us to investigate the usefulness of antibiotic …

There is a long history of local antibiotic use for the treatment of orthopedic infections (13,
19, 25, 34). During World War I, Alexander Fleming observed that locally applied antiseptics …

We fabricated batches of cement containing 0.5 gm, I. O gm* and 2.0 gm vancomycin and
one with 1.0 gm tobramycin and shaped them into cylinders. They were immersed into 0.5 L …

This study investigated the use of liquid gentamicin, a much less costly antibiotic (< 1/20 the
price of tobramycin) with a broad antimicrobial spectrum, alone and in combination with …

Increasing antibiotic resistance of bacteria that infect prosthetic joints has stimulated interest
in the incorporation of more effective antimicrobial agents into polymethylmethacrylate …

We used 99 strains of organisms representative of orthopaedic infections to examine the
effectiveness of a bone cement containing tobramycin, employing a modified in vitro Kirby …

Background Cancellous bone can act as a delivery vehicle for vancomycin without
impairment of graft incorporation. However, local and systemic antibiotic levels, biological …