Background and Purpose—S-nitrosylated hemoglobin (S-nitrosohemoglobin) has been
implicated in the delivery of O 2 to tissues through the regulation of microvascular blood …

In a rat model of middle cerebral artery occlusion (MCAo) and reperfusion (120 min),
previous studies have demonstrated that hemodilution with molecular hemoglobin …

The hemolysis of red blood cells after intracerebral hemorrhage (ICH) releases hemoglobin
degradation products and iron, which precipitate a cascade of events, including free …

Background Shock associated with traumatic brain injury (TBI) doubles the mortality of TBI
alone by inducing a secondary ischemic injury. Rapid correction of cerebral perfusion …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …

Background Brain tissue hypoxia (P bt O 2< 20 mmHg) is common after subarachnoid
hemorrhage (SAH) and associated with poor outcome. Recent data suggest that brain …

Background The prognostic impact of perihematomal hypoperfusion in patients with acute
intracerebral hemorrhage (ICH) remains unclear. We tested the hypothesis that …

Background and Purpose—Anemia is common after subarachnoid hemorrhage and may
exacerbate the reduction in oxygen delivery (DO2) underlying delayed cerebral ischemia …

Objective: Resuscitation of hemorrhagic hypotension after traumatic brain injury is
challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel …

Background: We previously reported that bovine polymerized hemoglobin (HBOC-201)
improved outcome in swine with hemorrhagic shock (HS) with and without traumatic brain …