Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with
nitroxide and polyethylene glycol moieties, showed neuroprotection vs. lactated Ringer's …

Background: Data are limited on the actions of hemoglobin based oxygen carriers (HBOCs)
after traumatic brain injury (TBI). This study evaluates neurotoxicity, vasoactivity, cardiac …

Following aneurysmal subarachnoid haemorrhage (SAH), cerebral blood flow (CBF) may be
reduced, resulting in poor outcome due to cerebral ischaemia and subsequent stroke …

Hemorrhagic strokes such as intracerebral hemorrhage (ICH) and subarachnoid
hemorrhage (SAH) are common diseases, but their effective treatments are limited. As a …

Background: Oxygenated sickle hemoglobin (HbS) does not polymerize; therefore,
increasing oxygen affinity to HbS is a therapeutic strategy for sickle cell anemia (SCA; HbSS …

Introduction Each unit of packed red blood cells (PRBCs) is expected to raise circulating
hemoglobin (HGB) by∼ 1 g/dL. There are few data on modifiers of this relationship other …

Hemodilution using modified hemoglobin solutions may reduce ischemic central nervous
system injury. Purified diaspirin cross-linked hemoglobin (DCLHb) is a cell-free hemoglobin …

✓ Hemodilution has been shown to increase cerebral blood flow (CBF) and reduce lesion
volume in models of occlusive cerebral ischemia, but it has not been evaluated in the setting …

Background Compromised cerebral blood flow (CBF) is a crucial factor in delayed cerebral
ischemia after subarachnoid hemorrhage (SAH). Repeated measurement of CBF may …

Background and Purpose—Diaspirin cross-linked hemoglobin (DCLHb) is a purified, cell-
free human hemoglobin solution. In animal stroke models its use led to a significant …