We hypothesized that targeting key points in the ischemic cascade with combined
neuroglobin (Ngb) overexpression and c-jun N-terminal kinase (JNK) inhibition (SP600125) …

Background Limited data are available to guide the choice of a target for the systolic blood-
pressure level when treating acute hypertensive response in patients with intracerebral …

Abstract Background Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow)
possesses superoxide dismutase/catalase mimetic activities that may directly protect the …

PURPOSE: Secondary brain ischaemia (SBI) usually develops after aneurysmal
subarachnoid haemorrhage (SAH) and severe traumatic brain injury (TBI). Current …

We investigated the effect of Rho kinase inhibition on changes in cerebral blood flow (CBF),
brain injury and vascular function after ischemic stroke in spontaneously hypertensive rats …

Introduction The benefits of correcting anemia using red blood cell transfusion (RBCT) after
subarachnoid hemorrhage (SAH) are controversial. We aimed to evaluate the role of anemia …

Hemodilution has had limited success as a treatment of cerebral ischemia. When using a
nonoxygen binding fluid, the therapeutic efficacy of hemodilution-induced increases in CBF …

Diaspirin cross-linked haemoglobin (DCLHb) is a new oxygen carrying blood substitute with
vasoactive properties. Vasoactive properties may be mediated via high affinity binding of …

Introduction: Traumatic shock and hemorrhage (TSH) is a leading cause of preventable
death in military and civilian populations. Using a TSH model, we compared plasma with …

OBJECTIVE Recent guidelines recommend targeting a systolic blood pressure (SBP)< 140
mm Hg in the early management of patients with spontaneous intracerebral hemorrhage …