[HTML][HTML] SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
S Stein, N Schäfer, A Breitenstein, C Besler… - Aging (Albany …, 2010 - ncbi.nlm.nih.gov
Excessive production of reactive oxygen species (ROS) contributes to progression of
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
Q Zhang, Z Wang, H Chen, S Zhou… - Cardiovascular …, 2008 - academic.oup.com
Aims Hazardous environmental and genetic factors can damage endothelial cells to induce
atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 …
atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 …
[HTML][HTML] SIRT6 protects against endothelial dysfunction and atherosclerosis in mice
SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA
damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is …
damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is …
The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
LB Gano, AJ Donato, HM Pasha… - American Journal …, 2014 - journals.physiology.org
Reductions in arterial SIRT1 expression and activity with aging are linked to vascular
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …
Protective roles of SIRT1 in atherosclerosis
S Stein, CM Matter - Cell cycle, 2011 - Taylor & Francis
SIRT1 is a NAD+-dependent class III histone deacetylase (HDAC) that mediates the effects
of caloric restriction on lifespan and metabolic pathways in various organisms. It …
of caloric restriction on lifespan and metabolic pathways in various organisms. It …
Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SirT1 activation
CL Kao, LK Chen, YL Chang, MC Yung… - … of atherosclerosis and …, 2010 - jstage.jst.go.jp
Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
Y xi Chen, M Zhang, Y Cai, Q Zhao, W Dai - Biochemical and biophysical …, 2015 - Elsevier
Activation of the silent mating type information regulation 2 homolog 1 (SIRT1) has been
shown consistent antiinflammatory function. However, little information is available on the …
shown consistent antiinflammatory function. However, little information is available on the …
SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis
Atherosclerosis is a chronic inflammatory disease that is based on the interaction between
inflammatory cell subsets and specific cells in the arterial wall. SIRT1 deacetylates histone …
inflammatory cell subsets and specific cells in the arterial wall. SIRT1 deacetylates histone …
Sirt1 inhibits oxidative stress in vascular endothelial cells
W Zhang, Q Huang, Z Zeng, J Wu… - … medicine and cellular …, 2017 - Wiley Online Library
The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a
barrier that mediates microenvironment homeostasis. Deterioration of either the structure or …
barrier that mediates microenvironment homeostasis. Deterioration of either the structure or …
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
Sirtuin 6 (SIRT6) is a chromatin-associated deacetylase that plays a leading role in genomic
stability and aging. However, the precise role of SIRT6 in atherosclerosis, an aging …
stability and aging. However, the precise role of SIRT6 in atherosclerosis, an aging …