Excessive production of reactive oxygen species (ROS) contributes to progression of
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …

Aims Hazardous environmental and genetic factors can damage endothelial cells to induce
atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 …

SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA
damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is …

Reductions in arterial SIRT1 expression and activity with aging are linked to vascular
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …

SIRT1 is a NAD+-dependent class III histone deacetylase (HDAC) that mediates the effects
of caloric restriction on lifespan and metabolic pathways in various organisms. It …

Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …

Activation of the silent mating type information regulation 2 homolog 1 (SIRT1) has been
shown consistent antiinflammatory function. However, little information is available on the …

Atherosclerosis is a chronic inflammatory disease that is based on the interaction between
inflammatory cell subsets and specific cells in the arterial wall. SIRT1 deacetylates histone …

The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a
barrier that mediates microenvironment homeostasis. Deterioration of either the structure or …

Sirtuin 6 (SIRT6) is a chromatin-associated deacetylase that plays a leading role in genomic
stability and aging. However, the precise role of SIRT6 in atherosclerosis, an aging …