Conclusions Human induced pluripotent stem cells (hiPSCs) exhibit unlimited self-renewal
potential and have the capacity to differentiate into somatic cell derivatives of all three germ …

Human induced pluripotent stem cell (hiPSC)-derived macrophages provide a valuable tool
for disease modeling and drug discovery. Here, we present a protocol to generate functional …

Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis.
Understanding of human macrophage biology has been hampered by the lack of reliable …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide
remarkable cellular platforms to better understand human hematopoiesis and to develop …

Granulocytes and macrophages are the frontline defenders of the innate immune system.
These myeloid cells play a crucial role in not only eliminating pathogens and tumor cells, but …

For the past decade, significant advances have been achieved in human hematopoietic
stem cell (HSC) transplantation for treating various blood diseases and cancers. However …

Cell therapies are currently used to treat many haematological diseases. These treatments
range from the long-term reconstitution of the entire haematopoietic system using the most …

Monocytes and macrophages are essential for immune defense and tissue hemostasis.
They are also the underlying trigger of many diseases. The availability of robust and short …

Summary Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of
hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and …

Significant advances in cellular reprogramming technologies and hematopoietic
differentiation from human pluripotent stem cells (hPSCs) have already enabled the routine …